Bose started his career as a theatre actor and soon bagged the lead role in ‘English, August’. It gained Bose international recognition when it became the first Indian film to be purchased by 20th Century Fox and won several awards at international film festivals.

In 2003, Bose made his debut in mainstream Bollywood cinema with ‘Jhankaar Beats’ and was later seen in ‘Mumbai Matinee’, ‘Chameli’, ‘Pyar Ke Side Effects’ and more. He then acted in ’15 Park Avenue’ (2006), which won the National Film Award for Best Feature Film in English.

He became India’s first Oxfam Global Ambassador in 2007 and is the founder and chair of Group Group, the governing body of 51 charities and NGOs in Mumbai. He is also an ambassador to the American Indian Foundation, the World Youth Peace Movement, and Planet Alert.

Bose offered his assistance in the relief efforts in the Andaman and Nicobar Islands after the 2004 Boxing Day tsunami. He launched a scholarship program that provides the education of underprivileged children from the Andaman and Nicobar Islands through his NGO, The Foundation. In 2011, he worked towards raising funds for victims of the Sikkim earthquake.